See subject. I don’t think this chain of calls makes a lot of sense.
We run MiniProfiler on our site, and don’t want it even spinning up on our production server, but do run it on our dev/staging servers.
We peppered our code with calls to MiniProfiler.Current (to trace specific methods) and found that calling that will force StackExchange.Profiling.UI.MiniProfilerHandler.RegisterRoutes to fire automagically.